Antimicrobial Stewardship
Principles and Practice

Cloth: 978 1 78064 439 4 / $250.00
Published: January 2017  

Publisher: CABI
450 pp., 7 1/2" x 9 5/8"
In an age where antimicrobial resistance among pathogens grows more prevalent, particularly in the hospital setting, antimicrobial stewardship is an evidence-based, proven measure in the battle against resistance and infection.

This comprehensive, definitive reference work is written by an international team of acknowledged experts in the field. The authors explore the effective use of coordinated antimicrobial interventions to change prescribing practice and help slow the emergence of antimicrobial resistance, ensuring that antimicrobials remain an effective treatment for infection.

Among the first of its kind, Antimicrobial Stewardship provides infectious disease physicians, administrators, laboratory, pharmacy, nursing, and medical staff practical guidance in setting up antimicrobial stewardship programs in their institutions with the aim of selecting the optimal antimicrobial drug regimen, dose, duration of therapy, and route of administration.

Table of Contents:
Part I: Overview of Antibiotic Stewardship
1: Principles of Antimicrobial Stewardship
2: Clinical Perspective of Antimicrobial Stewardship
3: History of Antimicrobial Stewardship
4: The Importance of Education in Antimicrobial Stewardship

Part II: Antibiotic Resistance Principles in Antibiotic Stewardship
5: Intrinsic and Acquired Mechanisms of Resistance
6: Antimicrobial Resistance: Selection vs. Induction
7: Colonization and its Importance for Emergence of Clinical Resistance
8: Antibiotic Resistance: Associations and Implications for Antibiotic Usage Strategies to Control Multi-resistant Bacteria

Part III: Microbiology Laboratory Role in Antibiotic Stewardship
9: The Role of Active Surveillance in the Prevention of Healthcare-acquired Infections and Antibiotic Stewardship
10: Role of Antibiogram in Antibiotic Stewardship
11: Selective Reporting and Antimicrobial Stewardship
12: Role of New Diagnostics to Enhance Antibiotic Stewardship Efforts

Part IV: Infection Control Aspects of Antibiotic Stewardship
13: Epidemiology of S Aureus and Enterococci in Children and an Overview of Antimicrobial Resistance
14: Epidemiology of Multi-drug Resistant Gram-negative Organisms
15: Pathogenesis and Epidemiology of Clostridium Difficile Infection: Implications for Antibiotic Stewardship
16: Role of the Hospital Epidemiologist in Supporting Antimicrobial Stewardship

Part V: Pharmacokinetic (PK) & Pharmacodynamic (PD) Aspects of Antibiotic Dosing in Antibiotic Stewardship
17: Principles of Pharmacokinetic / Pharmacodynamic Optimization for Antibiotic Dosing
18: Optimal use of Gram-negative Antibiotics in the Real World: Providing Effective Therapy While Minimizing Resistance
19: Optimal Use of Fluoroquinolones
20: Optimal Use of Beta-lactam Antibiotics
21: Current Approach to Optimal Use and Dosing of Vancomycin in Adult Patients
22: Principles of IV to PO Switch

Part VI: Pharmacy Department Role in Antibiotic Stewardship
23: Role of Pharmacists in Antimicrobial Stewardship
24: Formulary Management and Economic Considerations; Bridging the Gap between Quality Care and Cost
25: Approaches in Benchmarking
26: Development and Execution of Stewardship Interventions
27: Technologic Support for Antimicrobial Stewardship

Part VII: Measuring Outcomes in Antibiotic Stewardship Programs
28: Role of Guidelines and Statistical Milestones for Antimicrobial Stewardship
29: Economic Considerations of Antimicrobial Stewardship Programs
30: Pharmacoeconomic Implications of Antimicrobial Adverse Events
31: Antimicrobial Stewardship Programs in Areas of Increased Pathogen Resistance

Part VIII: Antimicrobial Stewardship and Various Practice Sites
32: Role of Antimicrobial Stewardship in Pediatrics
33: Antimicrobial Stewardship in the Intensive Care Unit
34: Role of Antimicrobial Stewardship in a Community Hospital
35: Outpatient Parenteral Antimicrobial Therapy (OPAT)
36: The Importance of Interdisciplinary Collaboration in Antimicrobial Stewardship: Immersion of Future Healthcare Professionals
37: Antimicrobial Stewardship and the Importance of Working with the Government and Pharmaceutical Industry
38: Hospitalist Perspective on the Role of Antimicrobial Stewardship